Mechanisms of immunosuppression by organotins
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چکیده
Mechanisms of immunosuppression by organotins – apoptosis vs. proliferative arrest-Proefschrift Universiteit Utrecht. Met een samenvatting in het Nederlands. Con un riassunto in Italiano. CONTENTS Chapter 1 General Introduction 5 Chapter 2 Organotin-induced apoptosis as observed in vitro is not relevant for induction of thymus atrophy at antiproliferative doses Chapter 3 Organotin-induced apoptosis occurs in small CD4 + CD8 + thymocytes and is accompanied by increased RNA synthesis Toxicol. Sciences. (Submitted) 41 Chapter 4 DBTC induces the synthesis of nur77 and GST involved in the apoptotic pathway 61 Chapter 5 Organotins induce apoptosis by disturbance of [Ca 2+ ] and mitochondrial activity, causing oxidative stress and activation of caspases in rat thymocytes Toxicol. Appl. Pharmacol. (Accepted) 75 Chapter 6 Thymus-independent inhibition of hapten-induced immunostimulation by the organotin compound DBTC
منابع مشابه
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Organotins present a toxicological risk to biota in the aquatic environment. Understanding the behaviour of these compounds in sediment is challenging, with sophisticated analytical techniques required for their measurement. We investigated the use of silica-bound sorbents for diffusive gradients in thin-films (DGT) adsorption gels to pre-concentrate five organotins (monobutlytin (MBT), dibutyl...
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تاریخ انتشار 2000